Labmanager 3 ng5/18/2023 ![]() VMLogix LabManager is an all-inclusive software lifecycle management solution which supports all leading enterprise-level virtualization platforms. XenSource was the commercial side of the open source Xen hypervisor, which was acquired by Citrix in October of that same year. The partnership is an extension of a relationship that was originally established in August 2007 between VMLogix and XenSource. 2004 Nov 26 279(48):50329-35.VMLogix is joining forces with Florida-based Citrix to make its virtual lab automation solution, VMLogix LabManager, the first solution of its kind available on the Citrix XenServer hypervisor. Smooth muscle selective alternatively spliced exon generates functional variation in Cav1.2 calcium channels. Liao P, Yu D, Lu S, Tang ZZ, Liang MC, Zeng S, Lin W, Soong TW. Selected Publications (* joint first author, † corresponding author) Use the letters in "FAST" to spot stroke signs and know when to call ambulance: Face drooping, Arm weakness, Speech difficulty, Time to call 995 (Singapore). Recanalisation beyond this time window may generate severe side effects such as malignant edema and hemorrhage due to vascular injury which can be potentially treated with our TRPM4 blocking antibody.Īs time is critical for stroke treatment, recognizing the signs of a stroke can save a life. The earlier the treatment, the better the result. Patients with tPA treatment have a much better outcome. Currently, the only FDA-approved treatment for ischemic strokes is tissue plasminogen activator (tPA) which must be given to eligible patients within a short time window (<4.5 hours after stroke onset). The goals of treatment of acute ischemic stroke are to restore blood flow. About 80 percent of strokes are ischemic strokes, caused by the blockage of a cerebral blood vessel. There are two types of stroke, ischemic and hemorrhagic. This medical emergency occurs when blood flow to an area of the brain is cut off. Stroke is a leading cause of death and disability worldwide. (D) Quantification of Evans blue extravasation demonstrates that M4P protects vasculature during reperfusion therapy. No difference was observed between M4P and control normoxia. M4P treatment significantly ameliorates cell swelling. (C) Cell swelling, exhibited as membrane capacitance Cm, was induced by hypoxia in control IgG treated cells. (B) Schematic representation of TRPM4 channel with the antigenic epitope for M4P labelled in red. TRPM4 inhibition by siRNA significantly reduces cerebral edema and infarct formation. Brain swelling was manifested as the midlines being shifted to the opposite hemisphere (arrows). (A) Exemplar images of T2WI and PET obtained from rats 24 hours post stroke reperfusion. TRPM4 inhibition protects blood-brain barrier after stroke reperfusion. We welcome collaborations from industry partners and philanthropic donation to co-develop the antibody and accelerate its translational process.įigure 1. In animal model of stroke, M4P was shown to protect vasculature after stroke reperfusion and potentially extend the time window of reperfusion therapy. M4P also exhibits the potential to benefit patients suffered from other brain disorders. We demonstrate that M4P could inhibit TRPM4 currents and subsequent cell swelling after hypoxia. A TRPM4 specific antibody M4P was thus developed in our lab to bind to and block the channel from extracellular space. We have shown that TRPM4 inhibition could reduce cerebral edema, a major side effect after reperfusion treatment. One example is Transient receptor potential melastatin member 4 (TRPM4) which is upregulated after stroke. We aim to develop novel treatments to correct the ionic imbalance and translate them into clinical practice which will benefit patients. The research in our lab is focused on ion channels and transporters that are key to the disruption of ionic homeostasis in brain disorders. ![]() As ions determine major brain functions such as firing of action potential, disruption of its homoeostasis worsens tissue damage in diseases of central nervous system such as stroke and head injury. Tel: (65) 6357 7611 (Office) / (65) 6357 7615 (Laboratory)Ĭellular ionic homeostasis is a dynamic state regulating ions such as calcium, sodium, and potassium both within the cell and across the cell membrane. ![]() West China University of Medical Sciences, Sichuan, China, 1996Ĭalcium Signalling Laboratory, Level 6, Lab 6 National University of Singapore, 2001īachelor of Medicine, Master of Surgery (Neurosurgery) Neuroscience Academic Clinical Program, SingHealth-Duke NUSĪssociate Professor (0.4FTE), Singapore Institute of TechnologyĪssociate Professor (Track IIA-research), Duke-NUS Graduate Medical School Principal Investigator and Head, Calcium Signalling Laboratory, NNI Deputy Director, Research (Basic Science & Translational Research), NNI
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